ABL1

ABL1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1AB2, 1AWO, 1BBZ, 1JU5, 1OPL, 1ZZP, 2ABL, 2E2B, 2FO0, 2G1T, 2G2F, 2G2H, 2G2I, 2GQG, 2HIW, 2HYY, 2HZ0, 2HZ4, 2HZI, 2V7A, 3CS9, 3EG0, 3EG1, 3EG2, 3EG3, 3EGU, 3K2M, 3QRI, 3QRJ, 3QRK, 3T04, 3UE4, 3UYO, 3PYY, 4J9B, 4J9C, 4J9D, 4J9E, 4J9F, 4J9G, 4J9H, 4J9I, 4JJB, 4JJC, 4JJD, 4TWP, 4WA9, 4XEY, 4YC8, 5DC9, 5DC4, 5DC0, 2O88, 5HU9
Dynodwyr
Cyfenwau	ABL1, ABL proto-oncogene 1, non-receptor tyrosine kinase, ABL, JTK7, bcr/abl, c-ABL, c-p150, v-abl, CHDSKM, BCR-ABL, Genes, abl
Dynodwyr allanol	OMIM: 189980 HomoloGene: 3783 GeneCards: ABL1
EC number	2.7.10.2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • actin monomer binding • protein domain specific binding • SH3 domain binding • kinase activity • protein C-terminus binding • signaling receptor binding • ATP binding • protein kinase activity • nicotinate-nucleotide adenylyltransferase activity • non-membrane spanning protein tyrosine kinase activity • metal ion binding • proline-rich region binding • magnesium ion binding • transferase activity • actin filament binding • GO:0001948, GO:0016582 protein binding • syntaxin binding • protein kinase C binding • DNA binding • nucleotide binding • manganese ion binding • mitogen-activated protein kinase binding • protein tyrosine kinase activity • four-way junction DNA binding • bubble DNA binding • phosphotyrosine residue binding • GO:0001105 transcription coactivator activity • neuropilin binding • SH2 domain binding • ephrin receptor binding • supercoiled DNA binding • sequence-specific double-stranded DNA binding Cydrannau o'r gell • cytoplasm • cytosol • nuclear membrane • bilen • extrinsic component of cytoplasmic side of plasma membrane • mitocondria • actin cytoskeleton • perinuclear region of cytoplasm • Cytosgerbwd • cnewyllyn cell • nucleolus • nucleoplasm • cell leading edge • nuclear body • dendrite • GO:0009327 protein-containing complex • neuronal cell body • postsynapse Prosesau biolegol • positive regulation of protein phosphorylation • B-1 B cell homeostasis • regulation of axon extension • neuromuscular process controlling balance • positive regulation of muscle cell differentiation • cellular response to DNA damage stimulus • protein phosphorylation • regulation of cell adhesion • regulation of microtubule polymerization • DNA damage induced protein phosphorylation • intrinsic apoptotic signaling pathway in response to DNA damage • positive regulation of ERK1 and ERK2 cascade • substrate adhesion-dependent cell spreading • platelet-derived growth factor receptor-beta signaling pathway • positive regulation of actin filament binding • B cell receptor signaling pathway • GO:0097285 apoptotic process • negative regulation of endothelial cell apoptotic process • cerebellum morphogenesis • regulation of actin cytoskeleton reorganization • GO:0009373 regulation of transcription, DNA-templated • epidermal growth factor receptor signaling pathway • Fc-gamma receptor signaling pathway involved in phagocytosis • establishment of protein localization • thymus development • negative regulation of phospholipase C activity • positive regulation of mitotic cell cycle • actin filament branching • spleen development • GO:0001306 response to oxidative stress • ffagocytosis • positive regulation of peptidyl-tyrosine phosphorylation • regulation of response to DNA damage stimulus • mitochondrial depolarization • positive regulation of Wnt signaling pathway, planar cell polarity pathway • platelet-derived growth factor receptor signaling pathway • regulation of endocytosis • activation of protein kinase C activity • regulation of actin cytoskeleton organization • phosphorylation • signal transduction in response to DNA damage • GO:1900490 positive regulation of oxidoreductase activity • positive regulation of release of sequestered calcium ion into cytosol • negative regulation of I-kappaB kinase/NF-kappaB signaling • regulation of cell motility • positive regulation of microtubule binding • cell adhesion • regulation of autophagy • peptidyl-tyrosine autophosphorylation • alpha-beta T cell differentiation • regulation of cellular senescence • negative regulation of protein serine/threonine kinase activity • actin cytoskeleton organization • negative regulation of cellular senescence • positive regulation of osteoblast proliferation • GO:0007067 Mitosis • activated T cell proliferation • endocytosis • negative regulation of cell-cell adhesion • B cell proliferation involved in immune response • cellular response to dopamine • positive regulation of cytosolic calcium ion concentration • positive regulation of neuron death • regulation of cell cycle • negative regulation of BMP signaling pathway • autophagy • B cell proliferation • negative regulation of ubiquitin-protein transferase activity • microspike assembly • positive regulation of apoptotic process • regulation of extracellular matrix organization • positive regulation of I-kappaB kinase/NF-kappaB signaling • negative regulation of ERK1 and ERK2 cascade • transitional one stage B cell differentiation • DNA mismatch repair • Bergmann glial cell differentiation • peptidyl-tyrosine phosphorylation • collateral sprouting • cellular response to lipopolysaccharide • negative regulation of mitotic cell cycle • cellular response to hydrogen peroxide • GO:0100026 DNA repair • innate immune response • neural tube closure • post-embryonic development • neuron differentiation • cellular response to oxidative stress • regulation of cell population proliferation • protein autophosphorylation • neuroepithelial cell differentiation • integrin-mediated signaling pathway • positive regulation of endothelial cell migration • cell differentiation • regulation of Cdc42 protein signal transduction • neuropilin signaling pathway • endothelial cell migration • regulation of T cell differentiation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • T cell receptor signaling pathway • positive regulation of stress fiber assembly • positive regulation of focal adhesion assembly • DNA conformation change • positive regulation of cell migration involved in sprouting angiogenesis • positive regulation of substrate adhesion-dependent cell spreading • negative regulation of long-term synaptic potentiation • regulation of hematopoietic stem cell differentiation • regulation of modification of synaptic structure • positive regulation of blood vessel branching • positive regulation of actin cytoskeleton reorganization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	25	n/a
Ensembl	ENSG00000097007	n/a
UniProt	P00519	n/a
RefSeq (mRNA)	NM_007313 NM_005157	n/a
RefSeq (protein)	NP_005148 NP_009297	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ABL1 yw ABL1 a elwir hefyd yn ABL proto-oncogene 1, non-receptor tyrosine kinase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 9, band 9q34.12.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ABL1.

• ABL
• JTK7
• p150
• c-ABL
• v-abl
• CHDSKM
• c-ABL1
• bcr/abl

Llyfryddiaeth

• "Atomic view of the energy landscape in the allosteric regulation of Abl kinase. ". Nat Struct Mol Biol. 2017. PMID 28945248.
• "Mutational analysis in BCR-ABL1 positive leukemia by deep sequencing based on nanopore MinION technology. ". Exp Mol Pathol. 2017. PMID 28663031.
• "Computational analysis of ABL kinase mutations allows predicting drug sensitivity against selective kinase inhibitors. ". Tumour Biol. 2017. PMID 28475010.
• "Clinical characteristics of patients with central nervous system relapse in BCR-ABL1-positive acute lymphoblastic leukemia: the importance of characterizing ABL1 mutations in cerebrospinal fluid. ". Ann Hematol. 2017. PMID 28451802.
• "Germline mutations in ABL1 cause an autosomal dominant syndrome characterized by congenital heart defects and skeletal malformations.". Nat Genet. 2017. PMID 28288113.